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Studies on gut microbiota transplantation in animals confirmed that dysbiosis may increase thyroid autoimmunity susceptibility [179]

Reduced muscle strength, fatigue, anorexia, low fat-free mass index, or abnormal biochemistry characterized by increased C-reactive protein (CRP) and IL-6 levels, as well as anemia and low serum albumin

451 In streptozotocin (STZ)-induced diabetic rat and mouse models, elevated expression of P2X2 and P2X3 receptors in the DRG, along with increased current density and P2X4 receptor expression on satellite glial cells, indicates that P2X4 receptor activation in the DRG significantly contributes to DPN-induced mechanical pain hypersensitivity (Fig

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