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FXR, a nuclear receptor activated by BAs, suppresses ferroptosis by upregulating the transcription of antioxidant genes such as GPX4 and FSP1

The tadalafil (TAD) group received daily oral gavage of 2 mg/kg tadalafil solubilized in a vehicle containing 0.5% carboxymethylcellulose sodium (CMC-Na) and 5% polyethylene glycol 300 (PEG300)

Deferoxamine Treatment Prevents Post-Stroke Vasoregression and Neurovascular Unit Remodeling Leading to Improved Functional Outcomes in Type 2 Male Diabetic Rats: Role of Endothelial Ferroptosis