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Hypothetical model of dynamic biomarkers of the Alzheimers pathological cascade

The regulatory pathways of ferroptosis are relatively complex and may involve multiple cross-signaling pathways, such as ROS generation, lipid peroxidation, autophagy, inflammatory response, etc

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a neurotransmitter deficiency state including the elevation of GABA (gamma-amino-benzoic acid), PEA (phenyl-ethyl-amine), and histamine, and more generally any abnormal alteration of excitatory or inhibitory neurotransmitters that result in a disease state

242 The depletion of p300 suppresses senescence-related gene expression, ensuing delayed senescence