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Description

In addition, baricitinib mainly acts on JAK1 and JAK3 and downregulates cytokines such as interferon-, IL-12, IL-17, and IL-23, 502,503 and ruxolitinib acts on JAK1 and JAK2, thereby inhibiting the phosphorylation of STAT3 and promoting Th17 cell apoptosis 504

This observation has significant physiological implications, suggesting that ABCC1 may regulate the labile iron pool, mitigate elevated intracellular iron levels, and contribute to defense against iron toxicity