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The microbiome-gut-brain content axis consists of three bidirectional, biochemical, signaling pathways between the gut and the brain, and these three pathways include the nervous, endocrine, and immune pathways (198)

However, retatrutide is not yet FDA approved and availability is limited to clinical trials and research settings

BDNF: Brain-Derived Neurotrophic Factor

While -synuclein (-Syn), which is encoded by SNCA , is one of the fundamental components in the Lewy body, patients with SNCA mutants (A30P, E46K, H50Q, G51D, A53E, and A53T) or multiplications are really rare, characterized by autosomal dominant inheritance, widely distributed age of onset (from 19 to 81 years), and more rapid cognitive impairment (Rosborough et al., 2017)

Per ASCO guidelines, duloxetine is the only agent with moderate evidence for CIPN pain relief