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The impact of YTHDF1 on the cell growth and chemoresistance were assessed using CCK-8 assays

The activated Nrf2-sMaf heterodimer binds to antioxidant response element (ARE) sequences in the promoter of a tandem of antioxidant genes, including heme oxygenase-1 (HMOX1), aldo-keto reductases, glutathione, and glutathione-S-transferase (Tonelli et al., 2018), to trigger their expression

Notably, despite being a large polyphenol, curcumin is lipophilic and can cross the bloodbrain barrier at sufficient concentrations to exert effects in the CNS (79)

Scientific Opinion on the Risks for Animal and Public Health Related to the Presence of T-2 and HT-2 Toxin in Food and feed1EFSA Panel on Contaminants in the Food Chain (CONTAM). European Food Safety Authority, 2011

Recently, Yu and Zhao reported that high dietary Mn intake leads to a decrease in Slc39a8 expression in the liver to prevent Mn overload in young mice but not in adult mice, suggesting an age-dependent difference in which hepatic Slc39a8 regulates Mn metabolism 42