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et al .) 317329 (Wiley-Blackwell, 2015)

However, it is nonspecific and can give rise to adverse secondary effects

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Metabolic disruption increases the risk of menstrual irregularity, ovulatory infertility, and adverse pregnancy outcomes

[6] [42] [43] For single doses of lipophilic, multi-compartment drugs, clinical duration after onset is often driven by the distribution () phase, because by the time distribution equilibrium is reached plasma levels are frequently below any minimal effective concentration, so the terminal phase has little bearing on observable effects