These help providers determine whether low glutathione is the primary issue or reflects broader metabolic dysfunction requiring different intervention
It has been extensively documented that HIF-1, functioning as a pivotal coregulator, exerts a positive regulatory influence on the expression of numerous pro-angiogenic genes and their corresponding receptors, including VEGF, placental growth factor (PIGF), and PDGF-B, among others
Abbreviations BaP: Benzo(a)pyrene PAHs: Polycyclic aromatic hydrocarbons IARC: The International Agency for Research on Cancer ROS: Reactive oxygen species BPDE: Benzo(a)pyrene-trans-7,8-dihydrodiol-9,10-epoxide AHR: Aryl hydrocarbon receptor Arnt: Aromatic receptor nuclear transporter TET: Ten-eleven translocation 5mC: 5-Methylcytosine 5hmC: 5-Hydroxymethylcytosine 5fC: 5-Formylcytosine 5caC: 5-Carboxylcytosine PGCs: Primordial germ cell TDG: Thymidine DNA glycosylase HCC: Hepatocellular carcinoma HB: Hepatoblastoma DNMTs: DNA methyltransferase SAM: S-Adenosylmethionine 16HBE: Human bronchial epithelial cells OGG1: 8-Oxoguanine DNA glycosylase RAR-2: Retinoic acid receptor-2 MLH1: MutL Homolog 1 NR2B: N-methyl-d-aspartate receptor subunit 2B FLT1: FMS-like tyrosine kinase-1 CYP450: CytochromeP450 GSTP: Glutathione-S-transferase-pi GNMT: Glycine N-methyltransferase GSTP1: Glutathione Stransferase P1 COX-2: Cyclooxygenase-2 MSH2: MutS homolog 2 PBMC: Peripheral blood mononuclear cells LCR: Lung Cancer Risk UBE2O: Ubiquitin-conjugating enzyme E2 O SAMD4A: Sterile alpha motif domain containing protein 4A ACBD6: Acyl-CoA binding domain-containing 6 DGK2: Diacylglycerol kinase 2 SLFN13: Schlafen 13 LINE-1: Long interspersed nucleotide element 1 MGMT: O6-methylguanine-DNA methyltransferase PSQ: Pyrosequencing XWLC: Xuanwei lung cancer BSP: Bisulfite sequencing PCR DKK2: Dickkopf-2 EN1: Engrailed 1 TRIM36: Tripartite motif containing 36 NSCLC: Non-small cell lung cancer F2RL3: Factor II receptor-like AHRR: Aryl hydrocarbon receptor repressor GC: Gastric cancer BCL6B: B-cell CLL/lymphoma 6 member B AIMS: Amplification of inter-methylated sites SINEs: Short interspersed nucleotide elements TSC2: Subunit 2 RAR: Retinoic acid receptor APC: Adenomatous polyposis coli DAPK: Death-associated protein kinase HIN1: Harpin-induced CDH1: Cadherin 1 DAPK-1: Death-associated protein kinase 1 Er: Estrogen receptors 5-Aza: 5-Azacytidine References Africander D, Storbeck KH
This condition is induced by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which primarily affects the lungs
& Taylor, F
