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Similarly, patient samples also showed, increased frequency of immature (CD56 ++ CD16 - ) NK cells and reduced mature (CD56 + CD16 + ) NK cells, along with diminished expression of maturation marker, CD57

This recommendation is based on an evaluation of the published clinical data on dosage and toxicology related considerations

These findings not only enrich the molecular understanding of senescent cell clearance but also provide a novel strategy for precise targeting of endothelial cell senescence in therapeutic applications

It also emphasizes the importance of following up with patients for symptoms of ED and utilization of alternative therapies to treat this clinical problem

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