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These endosomes subsequently transport the molecules across the cytoplasm for release on the other side

Funding This review was supported by the Natural Science Foundation of China (81974377), 345 Talent Project of Shengjing Hospital (20222025), and Outstanding Scientific Fund of Shengjing Hospital

tGSH was calculated as the sum of reduced GSH and two times the amount of oxidized glutathione (tGSH = GSH + 2 GSSG)

Endogenous sources of ROS Endogenous sources of ROS include various cellular organelles and enzymatic reactions within the body: Mitochondria Mitochondrial ROS generation primarily occurs at complexes I and III of the ETC due to electron leaks that fail to reach complex IV and instead univalently react with oxygen to form O 2