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While Esm1 + cells from the retina and embryonic intestine share expression of signature genes such as Esm1 , Flt4 (encoding the receptor tyrosine kinase VEGFR3) or Lama4 (laminin 4), the two populations show substantial differences in gene expression

In summary, current data support a model in which both LOXs and nonenzymatic Fenton chemistry contribute to lipid peroxidation during ferroptosis