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(1) Vitamin B12 (cobalamin) is most critical for neuronal health and blood cell formation, called hematopoiesis

Polymorphisms in various genes involved in vitamin B 12 metabolism, including the genes encoding the intrinsic factor-cobalamin receptor (60) and the holo-transcobalamin receptor (61), have been associated with increased NTD risk in some studies

On the other hand, the CaT group and positive drug group displayed the same effect after approximately 8 and 9 d, respectively

Other causes include gastrectomy, Crohn's disease, celiac disease, bariatric surgery, and chronic use of certain medications, such as proton pump inhibitors (PPIs) and metformin

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