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One possibility to overcome this issue is the use of non-toxic payloads, which have to be converted into their active form within the tumor cells

Metabolic outcomes from comparative studies mirror these mechanisms

In contrast, the OHE model, which utilized all features, showed weaker performance (AUC: 0.719 0.018, ACC: 0.731 0.014, PRC: 0.601 0.021), underscoring its limitations in capturing complex relationships within the data