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Lancet 371:6474 De Flora A, Benatti U, Guida L et al (1985) Favism: disordered erythrocyte calcium homeostasis

296 Microenvironmental modulators are employed to adjust local pH levels, thereby increasing the solubility of small molecules, biologics, and nucleic acid drugs in bodily fluids, or to modify processes that hinder drug efficacy and improve therapeutic outcomes in diseased tissues