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When an individual is healthy, AIM is in an inactivated state as a result of bonding with IgM, but when waste builds up in the body, AIM separates from IgM and bonds with the waste

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Additionally, the specific BMP antagonist gremlin induces LOX and LOXL1-4 expression through constitutively active TGF/Smad and inducible MAPK/JNK signaling pathways, suggesting BMPs may at least partially mediate enzymatic collagen crosslinking (Sethi et al ., 2013)