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Comorbid physical health outcomes in patients with bipolar disorder: an umbrella review of systematic reviews and meta-analyses

However, in high-risk populationsincluding patients with chronic kidney disease, granulomatous diseases, and primary hyperparathyroidismhypercalcemia may develop at substantially lower thresholds due to impaired Vitamin D 3 metabolism or unregulated extrarenal 1-hydroxylase activity

10.1038/nrgastro.2017.119 46 JrgensenJ.MortensenP

The rapid absorption not only maximizes the therapeutic potential of the vitamins but also minimizes any waiting period associated with conventional supplements