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In fact, in the absence of the nicotinamide coenzyme, the phenolic side chain of a tyrosine residue (e.g., Tyr 181 in the Gram-negative bacterium Pseudomonas putida ) covers the NAD + -binding pocket so as to protect FADH 2 from exposure to the solvent

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SnapShot: Insulin/IGF1 Signaling

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A distinct category of metabolite sensors, known as aryl hydrocarbon receptors (AhR), assimilates environmental, dietary, and microbial signals to regulate immunometabolic homeostasis