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doi: 10.1016/j.gendis.2018.05.001 2 WangD-YJiangZBen-DavidYWoodgettJRZacksenhausE

Hyperactivity of DNMTs leads to hypermethylation, particularly at promoter CpG islands of TSGs, silencing their expression and thereby promoting tumorigenesis (Jin and Liu 2018