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Research has indicated that dietary choices, particularly high-fat diets, significantly influence the gut microbiota, exacerbating DED symptoms through mechanisms such as decreased tear secretion, increased oxidative stress, and heightened apoptosis (Wu et al., 2020)

Ge XCZCL (2022) The antioxidant effect of the metal and metal-oxide nanoparticles

When GHK-Cu application stops, copper supplementation ceases potentially reducing these enzymatic activities if dietary copper intake and natural skin copper levels prove insufficient for maintaining treatment-level effects