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Several risk factors including age, hypertension, ischemic heart disease, diabetes, and chronic respiratory disease (Khanfar and Al Qaroot, 2020) increase the fatality rate (Ruan et al., 2020

H.HattingM.BottA.DahlhausenA.KellerD.TrautweinC.et al

Among them, the nuclear factor erythroid 2-related factor 2 (NRF2) reduces apoptosis, promotes cell migration, proliferation and cell differentiability by regulating the adaptive response to oxidative stress (Yu and Xiao, 2021)