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Metabolites of traditional Chinese medicine targeting PI3K/AKT signaling pathway for hypoglycemic effect in type 2 diabetes

SSC, Spermatogonial stem cell

These interactions play essential roles in modulating its localization, dimerization, and activation, ensuring that eNOS responds appropriately to cellular and environmental signals (Figure 4)

Building upon the detailed elucidation of the core molecular machinery governing ferroptosisincluding iron dysregulation, lipid peroxidation, antioxidant failure, and multilayered regulation by non-coding RNAsit becomes essential to establish a mechanistic bridge linking these fundamental processes to CVD pathophysiology