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The compounds discussed are not approved by the FDA for human or veterinary use

Koeppen S, Verstappen CC, Krte R, Scheulen ME, Strumberg D, Postma TJ, et al

In: BoskouD, editor

PB-TURSO (sodium phenylbutyrate + taurursodiol) Slowed AlSFRS-R decline in the phase 2/3 CENTAUR RCT (basis for 2022 FDA approval) but failed in the phase 3 PHOENIX trial and was voluntarily withdrawn from U.S./Canada in 2024

However, attempts to measure MTOB and homomethionine transport activity of recombinant BAT5 in vitro were not successful till now, as the direct measurements of transport of these substrates in artificial membranes is problematic due to higher hydrophobicity of substrates leading to unspecific membrane binding and permeation, which override the specific transport events (Gigolashvili et al., 2009)