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[4] [5] Some patients report temporary digestive changes following injections, though the exact mechanism for this is not well established

At Week 18, the mean relative change from baseline in LFC was -28.1% for Chiglitazar 48 mg (p = 0.004) and -39.5% for Chiglitazar 64 mg (p 60% of tested mice

DiazAOrejasJGrumleySNathHWangWDolliverWet al

Interestingly, all-trans retinoic acid (ATRA), an inhibitor of Pin1, inhibits the drug resistance of cells mainly by inhibiting the ERK 1/2 and AKT pathways (Huang et al., 2019)