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Subsequent crucial research involves the development of improved non-invasive biomarkers to detect and monitor pathological progression, including pathways related to genetics (such as mitochondrial or synaptic dysfunction)

Abbreviations AA : Arachidonic acid BCd : Blood cadmium BW : Body weight Ca : Calcium CAT : Catalase Cd : Cadmium -CEHC : 2,5,7,8-Tetramethyl-2(2-carboxyethyl)-6-hydroxychroman CLCE : Chronic low Cd exposure Cr : Creatinine Cu : Cuprum DMT1 : Divalent metal transporter 1 Co : Cobalt ER : Endoplasmic reticulum ETC : Electron transport chain Fe : Ferrum GBA : 4-Guanidinobutanoic acid GLCA : Glycolithocholic acid GPX : Glutathione peroxidase GR : Glutathione reductase GSA : Guanidinosuccinic acid GSH : Glutathione GUDCA : Glycoursodeoxycholic acid HCE : High cadmium exposure LPA : Lysophosphatidic acid LysoPC : Lysophosphatidylcholine LysoPE : Lysophosphatidylethanolamine 2-MG : 2-Microglobulin Mn : Manganese MT : Metallothionein NAG : N-Acetyl--D-glucosaminidase PAG : Phenylacetylglycine PAH : 4-Aminohippuric acid PC : Phosphatidylcholine PGE2 : Prostaglandin E2 PLA2 : PhospholipaseA2 PLD1 : Phospholipase D1 ROS : Reactive oxygen species SOD : Superoxide dismutase TCA : Tricarboxylic acid TDCA : Taurodeoxycholic acid TLCA : Taurolithocholic acid TRPV : Transient receptor potential cation channel subfamily V member UCd : Urinary cadmium Zn : Zinc ZIP : Zinc transporter References Adler T (2003) Aging research: the future face of environmental health

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