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Stephens et al., 2019)

Apparent suicide inactivation of human lymphoblast S-adenosylhomocysteine hydrolase by 2-deoxyadenosine and adenine arabinoside

Ethics declarations Ethics approval and consent to participant The program was approved by the National Center for Health Statistics Ethics Review Board

It depletes intracellular NAD+, directly poly(ADP-ribosyl)ates PPAR, and impairs both SIRT1 activity and the PPAR-mediated transcription of -oxidation genes, leading to suppressed mitochondrial function and fatty acid oxidation (61,62)