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PGs exert their effects by specific membrane-localized G protein-coupled receptors on the plasma membrane, and these prostanoid receptors are classified into five basic types: the PGD receptor (DP), the PGE receptor (EP1-4), the PGF receptor (FP), the PGI receptor (IP), and the thromboxane receptor (TP) (Narumiya and Fitzgerald, 2001)

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