l-carnitina efectos secundarios higado La carnitina, aminoácido, está presente en muchos alimentos, especialmente de origen animal. La carnitina también se sintetiza en el hígado, los riñones y el cerebro a partir de los aminoácidos lisina y Testimonios - Conoce El Antes

Vegetarians and vegans consume much less dietary carnitine, but healthy adults still synthesize carnitine

Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.) Pending Links ACTIUHUUMQJHFO-UPTCCGCDSA-N coenzyme Q10 Chemical compound COC1=C(OC)C(=O)C(C\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CCC=C(C)C)=C(C)C1=O ACTIUHUUMQJHFO-UPTCCGCDSA-N 0.000 title claims abstract description 65 PHIQHXFUZVPYII-ZCFIWIBFSA-N (R)-carnitine Chemical compound C[N+](C)(C)C[C@H](O)CC([O-])=O PHIQHXFUZVPYII-ZCFIWIBFSA-N 0.000 title claims abstract description 54 ACTIUHUUMQJHFO-UHFFFAOYSA-N Coenzym Q10 Natural products COC1=C(OC)C(=O)C(CC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)C)=C(C)C1=O ACTIUHUUMQJHFO-UHFFFAOYSA-N 0.000 title claims abstract description 53 235000017471 coenzyme Q10 Nutrition 0.000 title claims abstract description 53 239000008194 pharmaceutical composition Substances 0.000 title claims abstract description 36 238000002360 preparation method Methods 0.000 title claims abstract description 32 229940110767 coenzyme Q10 Drugs 0.000 title abstract description 7 150000003839 salts Chemical class 0.000 claims abstract description 63 239000002904 solvent Substances 0.000 claims abstract description 45 150000002148 esters Chemical class 0.000 claims abstract description 38 -1 polyoxyethylene Polymers 0.000 claims abstract description 32 229920003171 Poly (ethylene oxide) Polymers 0.000 claims abstract description 14 239000002202 Polyethylene glycol Substances 0.000 claims abstract description 14 229920001223 polyethylene glycol Polymers 0.000 claims abstract description 14 239000004359 castor oil Substances 0.000 claims abstract description 8 235000019438 castor oil Nutrition 0.000 claims abstract description 8 ZEMPKEQAKRGZGQ-XOQCFJPHSA-N glycerol triricinoleate Natural products CCCCCC[C@@H](O)CC=CCCCCCCCC(=O)OC[C@@H](COC(=O)CCCCCCCC=CC[C@@H](O)CCCCCC)OC(=O)CCCCCCCC=CC[C@H](O)CCCCCC ZEMPKEQAKRGZGQ-XOQCFJPHSA-N 0.000 claims abstract description 8 239000000243 solution Substances 0.000 claims description 76 235000002639 sodium chloride Nutrition 0.000 claims description 68 229960001518 levocarnitine Drugs 0.000 claims description 49 NPCOQXAVBJJZBQ-UHFFFAOYSA-N reduced coenzyme Q9 Natural products COC1=C(O)C(C)=C(CC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)C)C(O)=C1OC NPCOQXAVBJJZBQ-UHFFFAOYSA-N 0.000 claims description 46 229940035936 ubiquinone Drugs 0.000 claims description 46 238000000034 method Methods 0.000 claims description 20 238000003756 stirring Methods 0.000 claims description 20 KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims description 18 239000007924 injection Substances 0.000 claims description 18 238000002347 injection Methods 0.000 claims description 18 PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 17 VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 claims description 14 239000007788 liquid Substances 0.000 claims description 13 DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims description 12 239000003610 charcoal Substances 0.000 claims description 11 NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 claims description 10 FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims description 10 QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 claims description 9 OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims description 9 LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 9 KWYUFKZDYYNOTN-UHFFFAOYSA-M Potassium hydroxide Chemical compound [OH-].[K+] KWYUFKZDYYNOTN-UHFFFAOYSA-M 0.000 claims description 9 HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 claims description 9 229910052799 carbon Inorganic materials 0.000 claims description 9 239000003795 chemical substances by application Substances 0.000 claims description 9 BKVAAWMQOQLENB-UHFFFAOYSA-N 15-hydroxy stearic acid Chemical class CCCC(O)CCCCCCCCCCCCCC(O)=O BKVAAWMQOQLENB-UHFFFAOYSA-N 0.000 claims description 8 235000001014 amino acid Nutrition 0.000 claims description 8 150000001413 amino acids Chemical class 0.000 claims description 8 FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 claims description 7 239000003963 antioxidant agent Substances 0.000 claims description 7 235000006708 antioxidants Nutrition 0.000 claims description 7 239000006184 cosolvent Substances 0.000 claims description 7 235000011187 glycerol Nutrition 0.000 claims description 7 239000000843 powder Substances 0.000 claims description 7 239000000600 sorbitol Substances 0.000 claims description 7 235000010356 sorbitol Nutrition 0.000 claims description 7 GVJHHUAWPYXKBD-UHFFFAOYSA-N ()--Tocopherol Chemical compound OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 claims description 6 WCUXLLCKKVVCTQ-UHFFFAOYSA-M Potassium chloride Chemical compound [Cl-].[K+] WCUXLLCKKVVCTQ-UHFFFAOYSA-M 0.000 claims description 6 230000003078 antioxidant effect Effects 0.000 claims description 6 JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 claims description 6 BJEPYKJPYRNKOW-REOHCLBHSA-N (S)-malic acid Chemical compound OC(=O)[C@@H](O)CC(O)=O BJEPYKJPYRNKOW-REOHCLBHSA-N 0.000 claims description 5 ZEMPKEQAKRGZGQ-AAKVHIHISA-N 2,3-bis[[(z)-12-hydroxyoctadec-9-enoyl]oxy]propyl (z)-12-hydroxyoctadec-9-enoate Chemical class CCCCCCC(O)C\C=C/CCCCCCCC(=O)OCC(OC(=O)CCCCCCC\C=C/CC(O)CCCCCC)COC(=O)CCCCCCC\C=C/CC(O)CCCCCC ZEMPKEQAKRGZGQ-AAKVHIHISA-N 0.000 claims description 5 FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 claims description 5 108010010803 Gelatin Proteins 0.000 claims description 5 229930195725 Mannitol Natural products 0.000 claims description 5 229930006000 Sucrose Natural products 0.000 claims description 5 FEWJPZIEWOKRBE-UHFFFAOYSA-N Tartaric acid Natural products [H+].[H+].[O-]C(=O)C(O)C(O)C([O-])=O FEWJPZIEWOKRBE-UHFFFAOYSA-N 0.000 claims description 5 BJEPYKJPYRNKOW-UHFFFAOYSA-N alpha-hydroxysuccinic acid Natural products OC(=O)C(O)CC(O)=O BJEPYKJPYRNKOW-UHFFFAOYSA-N 0.000 claims description 5 229910000147 aluminium phosphate Inorganic materials 0.000 claims description 5 229920000159 gelatin Polymers 0.000 claims description 5 239000008273 gelatin Substances 0.000 claims description 5 235000019322 gelatine Nutrition 0.000 claims description 5 235000011852 gelatine desserts Nutrition 0.000 claims description 5 239000001630 malic acid Substances 0.000 claims description 5 235000011090 malic acid Nutrition 0.000 claims description 5 239000000594 mannitol Substances 0.000 claims description 5 235000010355 mannitol Nutrition 0.000 claims description 5 239000011780 sodium chloride Substances 0.000 claims description 5 239000005720 sucrose Substances 0.000 claims description 5 239000011975 tartaric acid Substances 0.000 claims description 5 235000002906 tartaric acid Nutrition 0.000 claims description 5 FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 claims description 4 WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims description 4 RVGRUAULSDPKGF-UHFFFAOYSA-N Poloxamer Chemical compound C1CO1.CC1CO1 RVGRUAULSDPKGF-UHFFFAOYSA-N 0.000 claims description 4 150000001447 alkali salts Chemical class 0.000 claims description 4 WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 claims description 4 239000008103 glucose Substances 0.000 claims description 4 229920001983 poloxamer Polymers 0.000 claims description 4 229960000502 poloxamer Drugs 0.000 claims description 4 229920000136 polysorbate Polymers 0.000 claims description 4 239000003381 stabilizer Substances 0.000 claims description 4 108010011485 Aspartame Proteins 0.000 claims description 3 FEWJPZIEWOKRBE-JCYAYHJZSA-N Dextrotartaric acid Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O FEWJPZIEWOKRBE-JCYAYHJZSA-N 0.000 claims description 3 KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 claims description 3 229920000715 Mucilage Polymers 0.000 claims description 3 OFOBLEOULBTSOW-UHFFFAOYSA-N Propanedioic acid Natural products OC(=O)CC(O)=O OFOBLEOULBTSOW-UHFFFAOYSA-N 0.000 claims description 3 CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 claims description 3 QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 claims description 3 229930003427 Vitamin E Natural products 0.000 claims description 3 TVXBFESIOXBWNM-UHFFFAOYSA-N Xylitol Natural products OCCC(O)C(O)C(O)CCO TVXBFESIOXBWNM-UHFFFAOYSA-N 0.000 claims description 3 239000002253 acid Substances 0.000 claims description 3 239000000853 adhesive Substances 0.000 claims description 3 150000001412 amines Chemical class 0.000 claims description 3 125000003118 aryl group Chemical group 0.000 claims description 3 239000000605 aspartame Substances 0.000 claims description 3 235000010357 aspartame Nutrition 0.000 claims description 3 IAOZJIPTCAWIRG-QWRGUYRKSA-N aspartame Chemical compound OC(=O)C[C@H](N)C(=O)N[C@H](C(=O)OC)CC1=CC=CC=C1 IAOZJIPTCAWIRG-QWRGUYRKSA-N 0.000 claims description 3 229960003438 aspartame Drugs 0.000 claims description 3 BVKZGUZCCUSVTD-UHFFFAOYSA-N carbonic acid Chemical compound OC(O)=O BVKZGUZCCUSVTD-UHFFFAOYSA-N 0.000 claims description 3 WIGCFUFOHFEKBI-UHFFFAOYSA-N gamma-tocopherol Natural products CC(C)CCCC(C)CCCC(C)CCCC1CCC2C(C)C(O)C(C)C(C)C2O1 WIGCFUFOHFEKBI-UHFFFAOYSA-N 0.000 claims description 3 235000001727 glucose Nutrition 0.000 claims description 3 239000004310 lactic acid Substances 0.000 claims description 3 235000014655 lactic acid Nutrition 0.000 claims description 3 VZCYOOQTPOCHFL-UPHRSURJSA-N maleic acid Chemical compound OC(=O)\C=C/C(O)=O VZCYOOQTPOCHFL-UPHRSURJSA-N 0.000 claims description 3 239000011976 maleic acid Substances 0.000 claims description 3 HEBKCHPVOIAQTA-UHFFFAOYSA-N meso ribitol Natural products OCC(O)C(O)C(O)CO HEBKCHPVOIAQTA-UHFFFAOYSA-N 0.000 claims description 3 150000007524 organic acids Chemical class 0.000 claims description 3 150000002989 phenols Chemical class 0.000 claims description 3 150000003904 phospholipids Chemical class 0.000 claims description 3 239000001103 potassium chloride Substances 0.000 claims description 3 235000011164 potassium chloride Nutrition 0.000 claims description 3 235000011121 sodium hydroxide Nutrition 0.000 claims description 3 LSNNMFCWUKXFEE-UHFFFAOYSA-L sulfite Chemical compound [O-]S([O-])=O LSNNMFCWUKXFEE-UHFFFAOYSA-L 0.000 claims description 3 239000001117 sulphuric acid Substances 0.000 claims description 3 235000011149 sulphuric acid Nutrition 0.000 claims description 3 VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 claims description 3 LENZDBCJOHFCAS-UHFFFAOYSA-N tris Chemical compound OCC(N)(CO)CO LENZDBCJOHFCAS-UHFFFAOYSA-N 0.000 claims description 3 229960000281 trometamol Drugs 0.000 claims description 3 150000003700 vitamin C derivatives Chemical class 0.000 claims description 3 235000019165 vitamin E Nutrition 0.000 claims description 3 229940046009 vitamin E Drugs 0.000 claims description 3 239000011709 vitamin E Substances 0.000 claims description 3 239000000811 xylitol Substances 0.000 claims description 3 235000010447 xylitol Nutrition 0.000 claims description 3 HEBKCHPVOIAQTA-SCDXWVJYSA-N xylitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)CO HEBKCHPVOIAQTA-SCDXWVJYSA-N 0.000 claims description 3 229960002675 xylitol Drugs 0.000 claims description 3 FTLYMKDSHNWQKD-UHFFFAOYSA-N (2,4,5-trichlorophenyl)boronic acid Chemical compound OB(O)C1=CC(Cl)=C(Cl)C=C1Cl FTLYMKDSHNWQKD-UHFFFAOYSA-N 0.000 claims description 2 IXPNQXFRVYWDDI-UHFFFAOYSA-N 1-methyl-2,4-dioxo-1,3-diazinane-5-carboximidamide Chemical compound CN1CC(C(N)=N)C(=O)NC1=O IXPNQXFRVYWDDI-UHFFFAOYSA-N 0.000 claims description 2 229920001817 Agar Polymers 0.000 claims description 2 229920001661 Chitosan Polymers 0.000 claims description 2 229920002472 Starch Polymers 0.000 claims description 2 UEDUENGHJMELGK-HYDKPPNVSA-N Stevioside Chemical compound O([C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1O[C@]12C(=C)C[C@@]3(C1)CC[C@@H]1[C@@](C)(CCC[C@]1([C@@H]3CC2)C)C(=O)O[C@H]1[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O1)O)[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O UEDUENGHJMELGK-HYDKPPNVSA-N 0.000 claims description 2 235000010489 acacia gum Nutrition 0.000 claims description 2 239000001785 acacia senegal l

matrix 10 G/L)

J.OriolA.et al (2017)

Int J Mol Sci 25(11):5571 Nah EH, Choi YJ, Cho S, Park H, Kim S, Kwon E, Cho HI (2024) Changes in nonalcoholic fatty liver disease and M2BPGi due to lifestyle intervention in primary healthcare