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The geometric mean ratio for the primary end point, midazolam AUC inf in the presence to absence of kratom, lay outside the predefined no-effect range (0.751.33)

Shang J, Zheng Y, Yang Y, Liu C, Geng Q, Tai W, Du L, Zhou Y, Zhang W, Li F (2018) Cryo-electron microscopy structure of Porcine deltacoronavirus spike protein in the prefusion state