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In AD, HSP70 and HSP90 directly interact with amyloid-, preventing its aggregation and promoting its clearance

CarvalhoRFHugueninGVLuizRRMoreiraASOliveiraGMRosaG.Intake of partially defatted Brazil nut flour reduces serum cholesterol in hypercholesterolemic patients-a randomized controlled trial

(2014) The initiation of free radical peroxidation of low-density lipoproteins by glucose and its metabolite methylglyoxal: a common molecular mechanism of vascular wall injure in atherosclerosis and diabetes, Mol

For example, complex I inhibition by rotenone produces matrix ROS and inhibits ROS from reverse electron transfer, while complex III inhibition with antimycin A generates ROS in the inter-membrane space (IMS) 1,12,55,56,57 (Fig

Through these pathways, MGO treatment decreases the membrane potential of BMEC mitochondria, reflecting a loss of mitochondrial integrity and functioning [65]