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While anecdotal evidence and ethnobotanical studies indicate significant therapeutic potential, scientific data remain limited

Some individuals have an immune response to these proteins, leading to inflammation and gut dysbiosis

10.1002/jhbp.256 J

Slight deviations in the closed-state fit likely originate from an ensemble of conformations or flexibility in regions such as UBA2UBA3, which exhibit lower confidence scores in the AlphaFold model and may allow for an expandable channel