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Intermediate monocytes in the bovine express the highest amount of MHCII on their cell surface, as well as produce the largest amount of reactive oxygen species and pro-inflammatory cytokines such as CXCL8, CXCL1, IL1B and TNF [46]

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Common reasons for an imbalanced ratio between phosphatidylcholine and cholesterol include: Fasting Overeating High-fat diet Ketogenic diet Vegan diets Protein deficiency Low dietary choline intake Low dietary glycine intake Methylation disregulation Dirty MTHFR Dirty PEMT Dehydration Low stomach acid Ongoing intake of proton pump inhibitors (PPIs) Bacterial overgrowth of specific bacteria such as certain Clostridia species What Happens When You Dont Have Healthy Bile Composition or Bile Flow