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Description

Aging and glaucoma Aging and cellular senescence represent a central risk factor for progression of glaucoma

At clinical concentrations, pretomanid does not inhibit major CYP isoenzymes, including CYP1A2, CYP2C8, CYP2C9, CYP2C19 or CYP2D6, and does not induce CYP2C9 or CYP3A4, limiting the potential for DDI trough CYPs

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However, when the GNA concentration is increased from 15 to 35 mg/mL, the rising viscosity of the emulsion can hinder the emulsification process, ultimately leading to an increase in particle size