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Despite advances in chemotherapy, radiotherapy, and targeted therapies, challenges such as poor drug accumulation, systemic toxicity, and multidrug resistance persist, partly due to elevated intracellular GSH levels that neutralize reactive therapeutics and reduce treatment response

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The deletion of Lats2 or Mst1 may trigger the accumulation of cholesterol by increasing sterol regulatory element binding protein (SREBP) activity

C., Heimberger, A

Hypoxia-inducible factor-2alpha is essential in activating the COX2/mPGES-1/PGE2 signaling axis in colon cancer