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Hydrochlorothiazide Hydrochlorothiazide had no adverse effects on the fertility of mice and rats of either sex in studies wherein these species were exposed, via their diet, to doses of up to 100 and 4 mg/kg/day, respectively, prior to mating and throughout gestation

While these results are highly encouraging, robust, large-scale human clinical trials are still needed to validate these effects and establish a definitive therapeutic profile in humans

Nevertheless, the homozygote mutant genotype leads to hyperhomocysteinemia only when plasma folate status is low in healthy subjects and in patients with cardiovascular disease, thus subjects with this MTHFR mutation may be sensitive to low folate intake (Christensen et al, 1997

The compound is not listed as a scheduled controlled substance under the international drug-control conventions or under the major national scheduling systems

2010, pp