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By contrast, compounds such as dioxins, phorbol esters, and some polychlorinated biphenyls primarily act as tumor promoters, stimulating chronic inflammation, altering key signaling pathways, and disrupting normal cell-cycle control without exerting direct genotoxic effects [256,257]

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Bi-directional permeability assay with Caco-2 cells Compounds were tested in a Caco-2 cell bi-directional permeability assay using an established contract research organization (Cyprotex