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Similarly, GPX4 activators and indirect inducers such as icariin or vitamin derivatives demonstrate antioxidant and chondroprotective effects in preclinical studies (25, 153, 156)

Charles W

Notably, lithium modulates inositol signaling, reduces intracellular inositol levels, and sensitizes neurons to serotonin, which may explain its efficacy in treatment-resistant depression and its augmentation of antidepressant effects

This animal model study put an emergent need to complete GSH supplementation trial in MCI and AD patients for cognitive improvement as proposed earlier