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High attrition rates ultimately made it difficult to draw firm conclusions, and no significant difference in neuropathy severity emerged between treatment and placebo arms at the final analysis (Guo 2014)

Several studies have indicated that hypercholesterolemia is associated with male infertility, including testicular and sperm dysfunction ( Excess oxidative stress resulting in overproduction of ROS and reductions in anti-oxidative enzymes has been demonstrated to be a possible mediator of male infertility ( Conclusion The results of this study demonstrated that a high-fat and high-cholesterol diet caused reduced hormone levels, decreased spermatogenesis and a poor semen quality through elevated oxidative stress, apoptosis, and inflammation

Further the drugs are becoming ineffective due to overuse which in turn is rendering toxicity to host

Thats partly to protect receiving environments from nutrient pollution and partly to expand water supplies by encouraging water reuse

To compare, GLP-1 are routinely demonstrating 7% placebo adjusted reduction at 12 weeks