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Neutrophil platelet endothelial cell adhesion molecule-1 participates in neutrophil recruitment at inflammatory sites and is down-regulated after leukocyte extravasation

Thereby, SemD binds to the BR-GBD via a bipartite interaction, which involves (i) the binding of positively charged amino acids located in the C-terminal BR domain to the negatively charged patch on SemD and (ii) the insertion of the CRIB domain into the binding groove provided by SemD