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The redox state of the GSH/GSSG couple can serve as an important indicator of redox environment (2931), and changes in this couple correlate with multiple cellular processes, including cell differentiation (3237), cell proliferation (3237), and cell apoptosis (3842)

Conversely, a V203A point mutation disrupting TRAF1/cIAP2 interaction blocks TAK1 phosphorylation downstream of TLR4, inhibiting NF-B/MAPK pathway activation and reducing joint inflammation in rheumatoid arthritis models (292)