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Adiga, R

Annals of Microbiology, 70 (1)

J Gastroenterol 2015;50:105468

In ovarian protection, melatonin promotes the phosphorylation of malic enzyme 1 (Mel), modulates NADPH levels, and enhances the activity of antioxidant enzymesincluding SOD, CAT, GPX and glutathione reductase (GR)along with GSH content., collectively restoring mitochondrial function and lessening granulosa cell apoptosis (152)

This depletion correlates directly with elevated ventricular lactate levels, providing concrete biological evidence that the brains of these patients are trapped in a state of high oxidative stress and inefficient anaerobic metabolism