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Neurosci Biobehav Rev 103:305315 Suzuki K, Miyamoto M, Miyamoto T, Uchiyama T, Watanabe Y, Suzuki S, Kadowaki T, Fujita H, Matsubara T, Sakuramoto H, Hirata K (2017) Istradefylline improves daytime sleepiness in patients with Parkinsons disease: an open-label, 3-month study