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These targeted agents exploit two central survival dependencies of CLL cells: chronic B-cell receptor (BCR) signaling mediated through BTK and a marked anti-apoptotic reliance on BCL2, respectively

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Unlike replacement of solutions by microperfusion (from 1 mM to 100 mM glutamate), EPSCs recovered with much faster kinetics upon glutamate uncaging with a time constant of ~15 s, which is 10100 times faster than those estimated in isolated vesicles (Naito and Ueda, Figure 3 Despite this first success toward estimating the rate of glutamate transport in living synapses, there remain several critical concerns regarding the protocol

The thyroid is one of the most metabolically active organs in the human body