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Quinone moiety Quinone moiety has also been utilized to develop hypoxia-triggered prodrug molecules owing to its ability to undergo electronic rearrangement to cleave covalent bonds under hypoxic conditions 123

Interestingly, the E3 ligase TRIM21 limits mtDNA release by promoting VDAC2 degradation

Does amnesia specifically predict Alzheimer's pathology

The mechanisms remain unknown and the possibility that GSL-degradation products - allyl-ITC in the present case - might trigger this response by being perceived as DAMPs by a receptor, such as one of those described above, either directly or indirectly constitutes an interesting aspect worthy of further investigations