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*Correspondence: Mohanned Naif Alhussien, [email protected] These authors share first authorship Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

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In fact, the GPx4 protein itself possesses a number of cysteine residues on its protein surface, which have been implicated in its ability to form extensive enzymatically inactive protein polymers (Scheerer et al., 2007)

For example, HF individuals with reduced ejection fraction are generally advised against participating in competitive sports, while those with HF and preserved ejection fraction, classified as low-risk, may engage in certain competitive activities