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Administration less frequent than twice weekly likely allows complete dissipation of synaptic changes between doses, preventing the cumulative structural modifications that constitute Dihexas therapeutic mechanism

Unhealthy diets, such as those high in fat, can induce oxidative stress, damaging tight junctions and altering bile acid secretion, increasing hydrophobic bile acids, and ultimately leading to ROS accumulation and oxidative stress in intestinal epithelial cells

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