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Cellular pathways affected by ototoxic drugs In various cell types, the transcription factor nuclear factor erythroid 2-related factor 2 (Nrf2) and the antioxidant response element (ARE) have been recognized as significant contributors in multiple cellular responses to oxidative stress (Kros and Steyger 2019

There is a consensus that GPX and GCL are the two enzymes in the glutathione pathway that are upregulated by estradiol

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Weishaupt JH, Bartels C, Polking E, Dietrich J, Rohde G, Poeggeler B, et al

The OGDHc has an intrinsic capacity to remove lipoyl intermediates dependent on NAD + and CoA (for example, succinyl-lipoate) (Extended Data Fig