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10.1152/jappl.1997.82.2.571 90 PaoneP.CaniP

For the 670 randomized patients, at study entry (Week 0) mean body weight was 107.3 kg and mean BMI was 38.4 kg/m2, and at randomization (Week 36, after the open-label ZEPBOUND lead-in period) mean body weight was 85.2 kg and mean BMI was 30.5 kg/m2

The next day, slides were washed in TBS for one minute, blocked with 3% Peroxide block (Cat# H312-500, Thermo Fisher Scientific) diluted 1:10 in PBS for 10 min, and then washed three times with TBS for three min

Loss of Kmt2c or Kmt2d drives brain metastasis via KDM6A-dependent upregulation of MMP3

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