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meningitidis activates both canonical and non-canonical pathways in the host, with predominance of the alternative caspase-3 mediated-GSDME activation in vitro in different cell lines (Tal et al., 2022) and of the GSDMD-dependent pathway in vivo in an intracisternal infected mouse model of meningitis (Pagliuca et al., 2024)

Omics : a journal of integrative biology

This suspension was then added to each well containing the hiPSCs with fresh mTeSR Plus media and incubated overnight in cell culture conditions

Using cultured neurons, Geisler and colleagues found that vincristine and bortezomib are able to induce an axonal degeneration program that involves the nicotinamide mononucleotide NMNAT2, SARM1, and the loss of NAD +