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Overview of AA metabolism The COX pathway As stated above, the term COX refers to enzymes also known as prostaglandin G/H synthases (PGHS), which metabolize AA to PGH 2 and PHG 2

White AM, Best PJ (2000) Effects of ethanol on hippocampal place-cell and interneuron activity

(Table 2) To facilitate the translation of mechanistic insights into clinical application, a phased, biomarker-guided approach incorporating preclinical pharmacokinetic studies, early-phase dose-escalation trials, and subsequent long-term randomized controlled trials may help define therapeutic dose ranges, inform safety considerations, and account for interindividual variability

And it should be noted that hormone therapy is not often recommended for women who smoke because it increases your risk for certain complications like blood clots