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One aspect of the invention pertains to small molecule quinoline derived cations of Formula I, wherein: R 1 is C 1-4 alkyl

A patient at a 0.50 mg maintenance dose draws 50 units per week about 10 weekly doses per vial

If hyperkalemia occurs, hydrochlorothiazide

This inflation-adjusted coinsurance amount is applied as a percent, as determined by the Secretary, to the payment amount that would otherwise apply for such calendar quarter in accordance with section 1847A(b)(1)(B) or (C) of the Act, as applicable, including in the case of a selected drug described under section 1192(c) of the Act

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